Cryo-EM

Derek Mendez and Xueli “Sherry” Zheng aim to accelerate drug discovery and improve energy storage.

SLAC scientists develop an approach to better guide the preparation of cell slices for cryogenic-electron tomography imaging.

His visit highlighted the breadth of our world-class research and the people and collaborations that make it possible. A key theme of the day: how SLAC and the National Labs are advancing AI to accelerate discovery.

Cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins. 

Researchers found a protein that's essential for an enterovirus to enter human cells. That could help the search for vaccines and treatments. 

The microelectronics that power daily life and speed discoveries in science and technology are the focus of a bold new vision to make them more energy efficient and able to operate in extreme environments.

Disabling those hinges could be a good strategy for designing vaccines and treatments against a broad range of coronavirus infections.

Peter Dahlberg has combined two complex imaging techniques into one. The 2021 Panofsky Fellow adds cryo-ET and biosensors to fluorescence microscopy to give context to high-resolution images of individual proteins in cells.

New SLAC-Stanford Battery Center bridges the gaps between discovering, manufacturing and deploying innovative energy storage solutions. 

Researchers used cryo-EM (left) to discover how a chamber in human cells (right) directs protein folding. 

Taking pictures of tiny, flash-frozen things with electrons is revolutionizing biology and technology. SLAC and Stanford host one of the world’s leading facilities for doing cryo-EM research, improving the technology and making it available to researchers across the country.

The leaders of SLAC's Technology Innovation Directorate discuss how their group supports the lab's most innovative projects.