The Cryo-EM (cryogenic electron microscopy) facility at SLAC, built and operated in partnership with Stanford University, is equipped with multiple state-of-the-art instruments for cryo-EM, a groundbreaking technology whose rapid development over the past few years has given scientists unprecedented views of the inner workings of the cell.
Cornelius Gati is publishing his research on tuberculosis. He works on tuberculosis samples at the cryo-EM facility. He freezes tuberculosis bacteria with liquid nitrogen to create pictures of the proteins the bacteria interacts with.
Lydia-Marie Joubert is pointing at the result of laminating an organic sample down to 100-300nm thickness for cryo-EM imaging. For samples which are traditionally too thick for imaging via cryogenic electron tomography (cryo-ET), a focused ion beam (FIB) can be...
The study, done on a mild-mannered relative of the virus that causes COVID-19, paves the way for seeing more clearly how spike proteins initiate infections, with an eye to preventing and treating them.