Cryo-EM lamellae

Cryo-EM computer image

Lydia-Marie Joubert is pointing at the result of laminating an organic sample down to 100-300nm thickness for cryo-EM imaging. For samples which are traditionally too thick for imaging via cryogenic electron tomography (cryo-ET), a focused ion beam (FIB) can be used to produce thin lamellae (~100-300 nm) from frozen, hydrated cells containing targets of interest.

Olivier Bonin/SLAC National Accelerator Laboratory

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