The researchers observed how an enzyme from drug-resistant tuberculosis bacteria damages an antibiotic molecule. The new technique provides a powerful tool to examine changes in biological molecules as they happen.
The National Institutes of Health center on the SLAC campus will make this revolutionary technology available to scientists nationwide and teach them how to use it to study 3D structures of biological machines and molecules.
The staff scientist at the Stanford Synchrotron Radiation Lightsource discusses his research and teaching, which includes training an international group of students to conduct geobiology experiments at the synchrotron from an island about 350 miles away.
With SLAC’s X-ray laser, a research team captured ultrafast changes in fluorescent proteins between “dark” and “light” states. The insights allowed the scientists to design improved markers for biological imaging.
A new X-ray laser technique allows scientists to home in on these single-electron triggers to better understand organic molecules that respond to light, including receptors in your eyes, plastic products and DNA building blocks that need to protect themselves from cancer-causing mutations.