X-ray Crystallography

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May 15, 2014
News Feature
Stanford ChEM-H: Chemistry, Engineering & Medicine for Human Health
Given a year to mature, the Institute for Chemical Biology is relaunching under a new name that better reflects its vision of bringing Stanford's unique interdisciplinary culture to bear at a new frontier of chemistry.
April 9, 2014
News Feature
Five Years of Illumination: SLAC's Linac Coherent Light Source
Five years ago, the brightest source of X-rays on the planet lit up at SLAC. The Linac Coherent Light Source (LCLS) X-ray laser's scientific and technical progress since its momentous "first light" have been no less luminous, say those who have played a role in its success.
Image - Some of the LCLS team members stand by the newly installed undulators in this 2009 photo. From right: Mike Zurawel, Geoff Pile from Argonne National Laboratory, Paul Emma, Dave Schultz, Heinz-Dieter Nuhn and Don Schafer. (Brad Plummer)
March 16, 2014
News Feature
Data-mining for Crystal 'Gold' at SLAC's X-ray Laser
A new tool for analyzing mountains of data from SLAC’s Linac Coherent Lightsource (LCLS) X-ray laser can produce high-quality images of important proteins using fewer samples. Scientists hope to use it to reveal the structures and functions of proteins that have proven elusive, as well as mine data from past experiments for new information
Photo - Nicholas Sauter, middle, points to a monitor during an experiment this month at SLAC's Linac Coherent Light Source X-ray laser.
December 19, 2013
Press Release
X-ray Laser Maps Important Drug Target
Researchers have used one of the brightest X-ray sources on the planet to map the 3-D structure of an important cellular gatekeeper known as a G protein-coupled receptor, or GPCR, in a more natural state than possible before.
Illustration - man with migraine, serotonin receptor bound to anti-migraine drug
November 25, 2013
Backstory: Marc Messerschmidt, Staff Scientist
Marc Messerschmidt, a staff scientist at the Coherent X-ray Imaging (CXI) experimental station at SLAC's Linac Coherent Light Source X-ray laser, describes his daily work, which is far from routine.
November 24, 2013
Press Release
Scientists Prove X-ray Laser Can Solve Protein Structures from Scratch
A study shows for the first time that X-ray lasers can be used to generate a complete 3-D model of a protein without any prior knowledge of its structure.
See caption
November 12, 2013
News Feature
Completing the Circuit: SLAC-designed Chips Empower X-ray Science
Scientists in SLAC's Integrated Circuits Department reach a new frontier in ultrafast X-ray science with intricately designed signal-processing chips that translate particles of light into bits of data.
Photo - Four ePix100 prototype chips bonded in a test setup. (Brad Plummer/SLAC)
August 28, 2013
News Feature
Ribosome Research Takes Shape at SLAC
In a new state-of-the-art lab at SLAC National Accelerator Laboratory, components of ribosomes – tiny biological machines that make new proteins and play a vital role in gene expression and antibiotic treatments – form crystals in a liquid solution.
Photo - Hasan Demirci, a visiting investigator from B...
August 8, 2013
News Feature
New Analysis Shows How Proteins Shift Into Working Mode
In an advance that will help scientists design and engineer proteins, a team including researchers from SLAC and Stanford has found a way to identify how protein molecules flex into specific atomic arrangements required to catalyze chemical reactions essential for life.
Image - This 3-D figure of the enzyme dihydrofolate r...
July 17, 2013
News Feature
New Program Broadens the Reach of LCLS Crystallography Experiments
A new screening program will allow researchers to quickly confirm whether precious biological samples yield useful information when struck by the intense X-ray pulses at SLAC's Linac Coherent Light Source (LCLS).
Photo - Marc Messerschmidt, a staff scientist who leads the Protein Crystal Screening Program at the Linac Coherent Light Source (LCLS) X-ray laser, works at the Coherent X-ray Imaging (CXI) experimental station. (Matt Beardsley)

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