The founding father of DNA nanotechnology – a field that forges tiny geometric building blocks from DNA strands – recently came to SLAC to get a new view of these creations using powerful X-ray laser pulses.
For decades, Nadrian C. "Ned" Seeman, a chemistry professor at New York University, has studied ways to assemble DNA strands into geometric shapes and 3-D crystals with applications in biology, biocomputing and nanorobotics.
Daniel DePonte, a pioneer in finding ways to serve up a steady and precise supply of crystals, viruses and other precious samples for laser experiments, is the newly hired sample-delivery group leader for SLAC’s Linac Coherent Light Source X-ray laser.
Understanding why proteins interact with certain specific molecules and not with the myriad others in their environment is a major goal of molecular biology. Now, in a series of recent papers, researchers describe how they designed proteins from scratch to have a high affinity and high specificity for targets on flu viruses, and then validated the two best designs using X-ray diffraction data collected at the Stanford Synchrotron Radiation Lightsource (SSRL).