X-ray Crystallography

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December 19, 2013
Press Release
Researchers have used one of the brightest X-ray sources on the planet to map the 3-D structure of an important cellular gatekeeper known as a G protein-coupled receptor, or GPCR, in a more natural state than possible before.
Illustration - man with migraine, serotonin receptor bound to anti-migraine drug
November 25, 2013
Marc Messerschmidt, a staff scientist at the Coherent X-ray Imaging (CXI) experimental station at SLAC's Linac Coherent Light Source X-ray laser, describes his daily work, which is far from routine.
November 24, 2013
Press Release
A study shows for the first time that X-ray lasers can be used to generate a complete 3-D model of a protein without any prior knowledge of its structure.
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November 12, 2013
News Feature
Scientists in SLAC's Integrated Circuits Department reach a new frontier in ultrafast X-ray science with intricately designed signal-processing chips that translate particles of light into bits of data.
Photo - Four ePix100 prototype chips bonded in a test setup. (Brad Plummer/SLAC)
August 28, 2013
News Feature
In a new state-of-the-art lab at SLAC National Accelerator Laboratory, components of ribosomes – tiny biological machines that make new proteins and play a vital role in gene expression and antibiotic treatments – form crystals in a liquid solution.
Photo - Hasan Demirci, a visiting investigator from B...
August 8, 2013
News Feature
In an advance that will help scientists design and engineer proteins, a team including researchers from SLAC and Stanford has found a way to identify how protein molecules flex into specific atomic arrangements required to catalyze chemical reactions essential for life.
Image - This 3-D figure of the enzyme dihydrofolate r...
July 17, 2013
News Feature
A new screening program will allow researchers to quickly confirm whether precious biological samples yield useful information when struck by the intense X-ray pulses at SLAC's Linac Coherent Light Source (LCLS).
Photo - Marc Messerschmidt, a staff scientist who leads the Protein Crystal Screening Program at the Linac Coherent Light Source (LCLS) X-ray laser, works at the Coherent X-ray Imaging (CXI) experimental station. (Matt Beardsley)
May 9, 2013
News Feature
Last year's Nobel Prize in Chemistry – shared by Stanford School of Medicine Professor Brian Kobilka and Robert Lefkowitz of Duke University – recognized groundbreaking research in G protein-coupled receptors (GPCRs).
Image: Researchers Dingjie Wang and Garret Nelson fro...
March 11, 2013
News Feature
The founding father of DNA nanotechnology – a field that forges tiny geometric building blocks from DNA strands – recently came to SLAC to get a new view of these creations using powerful X-ray laser pulses.
Image - Six-sided structure formed by DNA strands.
February 14, 2013
Press Release
Menlo Park, Calif. — Opening a new window on the way plants generate the oxygen we breathe, researchers used an X-ray laser at the Department of Energy’s (DOE) SLAC National Accelerator Laboratory to simultaneously look at the structure and chemical behavior of a natural catalyst involved in photosynthesis for the first time.
Microscope image of photosystem crystals

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