Structural Molecular Biology

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Scientists Map Protein in Living Bacterial Cells

Scientists have for the first time mapped the atomic structure of a protein within a living cell. The technique, which peered into cells with an X-ray laser, could allow scientists to explore some components of living cells as never before.

Five Years of Illumination: SLAC's Linac Coherent Light Source

Five years ago, the brightest source of X-rays on the planet lit up at SLAC. The Linac Coherent Light Source (LCLS) X-ray laser's scientific and technical progress since its momentous "first light" have been no less luminous, say those who have played a role in its success.

Data-mining for Crystal 'Gold' at SLAC's X-ray Laser

A new tool for analyzing mountains of data from SLAC’s Linac Coherent Lightsource (LCLS) X-ray laser can produce high-quality images of important proteins using fewer samples. Scientists hope to use it to reveal the structures and functions of proteins that have proven elusive, as well as mine data from past experiments for new information

X-ray Laser Maps Important Drug Target

Researchers have used one of the brightest X-ray sources on the planet to map the 3-D structure of an important cellular gatekeeper known as a G protein-coupled receptor, or GPCR, in a more natural state than possible before.

Hijacked Protein May Lead to New Therapeutic Interventions

Researchers hope to hijack a natural process called RNA interference to block the production of proteins linked to disease and treat medical conditions for which conventional drugs do not work, including cancer, heart disease, HIV and Parkinson’s disease.