LCLS Coherent X-ray Imaging (CXI)
In a new state-of-the-art lab at SLAC National Accelerator Laboratory, components of ribosomes – tiny biological machines that make new proteins and play a vital role in gene expression and antibiotic treatments – form crystals in a liquid solution.
Signs at the lab's entryway warn of the potential for contamination – these delicate samples can be damaged by human touch, a sneeze or a dust particle.
A high-energy SLAC laser that creates shock waves and superhot plasmas needs to cool for about 10 minutes between shots. In the meantime, the rapid-fire pulses produced by SLAC's Linac Coherent Light Source X-ray laser, which probes the extreme states of matter produced by this initial laser shot, are unused.
A new screening program will allow researchers to quickly confirm whether precious biological samples yield useful information when struck by the intense X-ray pulses at SLAC's Linac Coherent Light Source (LCLS).
Last year's Nobel Prize in Chemistry – shared by Stanford School of Medicine Professor Brian Kobilka and Robert Lefkowitz of Duke University – recognized groundbreaking research in G protein-coupled receptors (GPCRs). GPCRs are embedded in cell membranes. They interact with signaling molecules outside of cells and trigger responses within cells.
The founding father of DNA nanotechnology – a field that forges tiny geometric building blocks from DNA strands – recently came to SLAC to get a new view of these creations using powerful X-ray laser pulses.
For decades, Nadrian C. "Ned" Seeman, a chemistry professor at New York University, has studied ways to assemble DNA strands into geometric shapes and 3-D crystals with applications in biology, biocomputing and nanorobotics.