The researchers observed how an enzyme from drug-resistant tuberculosis bacteria damages an antibiotic molecule. The new technique provides a powerful tool to examine changes in biological molecules as they happen.
Experiments at SLAC heated water from room temperature to 100,000 degrees Celsius in less than a millionth of a millionth of a second, producing an exotic state of water that could shed light on Earth’s most important liquid.
With SLAC’s X-ray laser, a research team captured ultrafast changes in fluorescent proteins between “dark” and “light” states. The insights allowed the scientists to design improved markers for biological imaging.
X-ray studies have produced surprising insights into the workings of a hormone receptor associated with blood pressure regulation that could be a target for new medicines related to cardiovascular conditions, neuropathic pain and tissue growth.
Scientists used SLAC's LCLS X-ray laser to make the first snapshots of a chemical interaction between two biomolecules. It changes the shape of millions of molecular switches almost instantaneously, like synchronized swimmers performing the same move.